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Title: Electro-chemical oxidation and determination of granulocytosis risk inducing drug 4-aminoantipyrine at gold electrode
Authors: Gowda, Jayant I
Hanabaratti, Rohini M
Nandibewoor, Sharanappa T
Keywords: 4-Aminoantipyrine;Gold electrode;Electro-oxidation;Diffusion controlled process;Detection limit;Recovery study
Issue Date: Feb-2021
Publisher: NISCAIR-CSIR, India
Abstract: A voltammetric technique for electrochemical sensing and quantification of granulocytosis risk inducing metabolite of aminopyrine, 4-Aminoantipyrine (4-AAP) at gold electrode has been developed. The gold electrode shows excellent selectivity and sensitivity towards the oxidation of 4-AAP in phosphate buffer solution (PBS) of pH=3.0. It is observed from the electrochemical studies of scan rate that overall electrode process is diffusion controlled and pH effect suggests involvement of protons in electrochemical oxidation of 4-AAP. A linear current response towards the electrochemical oxidation of 4-AAP in the concentration range of 1.0 × 10-6 – 2.5 × 10−5 M is observed with limit of detection of 3.8 × 10-8 M (S/N = 3). The interference studies have shown that the gold electrode exhibited excellent selectivity in presence of large excess of interferents. The method is employed to recovery study of 4-AAP in spiked urine and serum samples.
Page(s): 228-235
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.60A(02) [February 2021]

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