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Title: Bioprospecting of the underutilized endemic taxon Cissus woodrowii (Stapf ex Cooke) Santapau for its antioxidant activity and phenolic profiling
Authors: Kolap, Rupali Mukesh
Gulave, Akshay Bharat
Zimare, Saurabha Bhimrao
Keywords: Antioxidant activity;Cissus woodrowii;HPLC;LC-HRMS;Phenolic profiling;Woodrow’s grape tree
Issue Date: Dec-2020
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2015.01)− A61K 36/00, A61K 36/87, A61K 127/00, A61P 39/00
Abstract: The present study explored the antioxidant potential of endemic Cissus woodrowii (CW) which is an underutilised tree taxon of the Vitaceae family. Maximum per cent yield (13.49%), total phenolic content (24.14 mg TAE/g dry weight), and total flavonoid content (18.45 mg QE/g dry weight) were recorded in the methanolic leaf extract. Whereas the in vitro antioxidant activities of different extracts were assessed using 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid), 2,2-diphenyl-1-picrylhydrazyl, hydroxyl, nitric oxide, hydrogen peroxide percent radical scavenging activity (% RSA), antioxidant power assay (ferric-reducing antioxidant power), and total antioxidant capacity (phosphomolybdate assay). Antioxidant activity of CW extract may be due to its high level of phenolic compounds, which were screened through liquid chromatography–high-resolution mass spectrometry (LC-HRMS), and the selected three phenolic compounds were quantified using high-performance liquid chromatography (HPLC). The HPLC analysis revealed a higher concentration of gallic acid (119.78 µg/g dry weight), followed by quercetin (22.13 µg/g dry weight) and embelin (21.09 µg/g dry weight). This is the first report on this underexplored taxon which could be employed for the development of several nutraceuticals and pharmaceuticals.
Page(s): 250-259
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.11(4) [December 2020]

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