Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/56140
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dc.contributor.authorKetha, Alekhya-
dc.contributor.authorVedula, Girija Sastry-
dc.date.accessioned2021-02-04T09:06:42Z-
dc.date.available2021-02-04T09:06:42Z-
dc.date.issued2020-12-
dc.identifier.issn0976-0512 (Online); 0976-0504 (Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/56140-
dc.description312-319en_US
dc.description.abstractIn this study, three known flavonols, namely kaempferol (1), ombuin (2), and quercetin (3), and three known 1,2-diphenylethanes, namely 5-(2-hydroxyphenethyl)-3-methoxy-2-methylphenol (4), 2-(3,5-dimethoxyphenethyl) phenol (5) and 2-(2-hydroxyphenethyl)-4,6-dimethoxyphenol (6) from the methanolic extract (ME) of Bauhinia vahlii were identified and sucessfully isolated. They were also evaluated for in vitro antioxidant, anti-inflammatory, anti-gout and anticancer effects. Compound 3 (26.00±2.17 µg/mL) showed an almost equivalent IC50 value of standard drug (25.55±2.80 µg/mL) against superoxide free radicals. Moreover, compound 3 showed significant inhibition of COXs and 5-LOX enzymes, while compounds 1, 2, 4 and 5 exhibited good inhibition of XO enzymes. Except for compound 5, all compounds showed a significant reduction of cell growth lysis of MCF-7, DLD-1, HeLa, and A549. Besides, all the metabolites and ME showed a very weak degree of specificity against NHME, indicates less toxicity to normal cells. The results suggest that B. vahlii can be a favourable natural source for the treatment of oxidative stress, inflammation, gout and cancer, and these actions are linked to the natural active compounds 1, 3, 4 and 6.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.ispartofseriesInt. cl. (2015.01)- A61K 36/00, A61K 36/48, A61P, A61P 29/00, A61P 39/06en_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJNPR Vol.11(4) [December 2020]en_US
dc.subjectAnticanceren_US
dc.subjectAnti-gouten_US
dc.subjectAnti-inflammatoryen_US
dc.subjectAntioxidanten_US
dc.subjectBauhinia vahliien_US
dc.subjectSulforhodamine B assayen_US
dc.titleIsolation, characterization, and biological evaluation of flavonols and 1,2-diphenylethanes from Bauhinia vahliien_US
dc.typeArticleen_US
Appears in Collections:IJNPR Vol.11(4) [December 2020]

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