Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/55941
Title: Synthesis and characterization of a new water-soluble non-cytotoxic mito-tracker capped silicon quantum dot
Authors: Saha, Subrata Kumar
Saha, Swadhin Kumar
Dhara, Koushik
Chattopadhyay, Pabitra
Sarkar, Arnab
Keywords: Silicon quantum dots;Fluorescence;XPS;Cytotoxicity;Mitochondrial target
Issue Date: Jan-2021
Publisher: NISCAIR-CSIR, India
Abstract: Allyl triphenylphosphonium bromide based mito-tracker capped silicon quantum dot (Mito-SiQDs) has been synthesized through an inverse micelle process. It was then fully characterized by transmission electron microscopy, energy-dispersive X-ray spectroscopy, dynamic light scattering techniques and X-ray photoelectron spectroscopic method. Energy dispersive X-ray spectroscopy analyses of the quantum dots confirm the presence of carbon, silicon, phosphorous and bromine atoms in Mito-SiQDs. Morphological study by transmission electron microscopy experiment showed the formation of the particles of size 11-12 nm of quantum dot dimension. The high negative zeta potential value of –23.7 mV calculated from dynamic light scattering study indicates the high stability of the circumvent agglomeration of Mito-SiQDs. The mito-tracker capped silicon quantum dot has blue emission at 400 nm wavelength upon excitation at 327 nm. Mito-SiQDs has not shown any significant cytotoxic effect with 10 to 50 μL/mL concentration on HeLa cell line for at least up to 12 h of its treatment. The Mito-SiQDs would be useful a possible fluorescent marker to visualize mitochondrial subcellular compartment in living cell through fluorescence imaging study.
Page(s): 19-25
URI: http://nopr.niscair.res.in/handle/123456789/55941
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.60A(01) [January 2021]

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