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|Title:||Synthesis and characterization of a new water-soluble non-cytotoxic mito-tracker capped silicon quantum dot|
|Authors:||Saha, Subrata Kumar|
Saha, Swadhin Kumar
|Keywords:||Silicon quantum dots;Fluorescence;XPS;Cytotoxicity;Mitochondrial target|
|Abstract:||Allyl triphenylphosphonium bromide based mito-tracker capped silicon quantum dot (Mito-SiQDs) has been synthesized through an inverse micelle process. It was then fully characterized by transmission electron microscopy, energy-dispersive X-ray spectroscopy, dynamic light scattering techniques and X-ray photoelectron spectroscopic method. Energy dispersive X-ray spectroscopy analyses of the quantum dots confirm the presence of carbon, silicon, phosphorous and bromine atoms in Mito-SiQDs. Morphological study by transmission electron microscopy experiment showed the formation of the particles of size 11-12 nm of quantum dot dimension. The high negative zeta potential value of –23.7 mV calculated from dynamic light scattering study indicates the high stability of the circumvent agglomeration of Mito-SiQDs. The mito-tracker capped silicon quantum dot has blue emission at 400 nm wavelength upon excitation at 327 nm. Mito-SiQDs has not shown any significant cytotoxic effect with 10 to 50 μL/mL concentration on HeLa cell line for at least up to 12 h of its treatment. The Mito-SiQDs would be useful a possible fluorescent marker to visualize mitochondrial subcellular compartment in living cell through fluorescence imaging study.|
|Appears in Collections:||IJC-A Vol.60A(01) [January 2021]|
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