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dc.contributor.authorNagababu, Penumaka-
dc.contributor.authorThulasiram, B-
dc.contributor.authorNagarkar, Jidnyasa-
dc.contributor.authorDevi, C Shobha-
dc.contributor.authorPaul, Perala Sudheer-
dc.contributor.authorReddy, Thatiparthi Byragi-
dc.identifier.issn0975-0975(Online); 0376-4710(Print)-
dc.description.abstractFour imidazo-phenanthroline (IP) based ligands and its corresponding copper polypyridyl complexes have been prepared [Cu(L1-L4)2]2+ and characterized by various physicochemical techniques. Herein we are reporting the CT-DNA (calf-thymus DNA) binding & anti-cancer affinity of ligands (L1-L4) as well as complexes (C1-C4). The DNA binding affinity of synthesized C1-C4 has been carried out by using spectroscopic techniques like UV/visible, emission, molecular modeling and viscosity techniques. The obtained results are clearly indicating that all C1-C4 complexes bind to DNA via intercalative mode and they possess a significant cytotoxic effect toward selected cancer cell lines (MDA-MB-231, B16-F10, DU-145 and CHO-K1).en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-A Vol.60A(01) [January 2021]en_US
dc.subjectCu(II) complexesen_US
dc.subjectDocking studiesen_US
dc.subjectAnti-cancer activityen_US
dc.titleCT-DNA-binding and biological activity of mononuclear copper(II) complexes with imidazo-phenanthroline ligandsen_US
Appears in Collections:IJC-A Vol.60A(01) [January 2021]

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