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Title: CT-DNA-binding and biological activity of mononuclear copper(II) complexes with imidazo-phenanthroline ligands
Authors: Nagababu, Penumaka
Thulasiram, B
Nagarkar, Jidnyasa
Devi, C Shobha
Paul, Perala Sudheer
Reddy, Thatiparthi Byragi
Keywords: Cu(II) complexes;DNA-binding;Docking studies;Anti-cancer activity
Issue Date: Jan-2021
Publisher: NISCAIR-CSIR, India
Abstract: Four imidazo-phenanthroline (IP) based ligands and its corresponding copper polypyridyl complexes have been prepared [Cu(L1-L4)2]2+ and characterized by various physicochemical techniques. Herein we are reporting the CT-DNA (calf-thymus DNA) binding & anti-cancer affinity of ligands (L1-L4) as well as complexes (C1-C4). The DNA binding affinity of synthesized C1-C4 has been carried out by using spectroscopic techniques like UV/visible, emission, molecular modeling and viscosity techniques. The obtained results are clearly indicating that all C1-C4 complexes bind to DNA via intercalative mode and they possess a significant cytotoxic effect toward selected cancer cell lines (MDA-MB-231, B16-F10, DU-145 and CHO-K1).
Page(s): 37-44
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.60A(01) [January 2021]

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