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Title: A convenient synthesis and biological activities of N-(pyridin-3-ylmethylene) benzohydrazides by the condensation of nicotinaldehydes with benzohydrazides
Authors: Anusha, D
Praveena, G
Zehra, A
Tiwari, A K
Prakasham, R S
Raju, B China
Keywords: N'-Pyridinylmethylenebenzohydrazides;Nicotinaldehydes;Benzohydrazides;Anti-microbial activity;Anti-hyperglycemic activity
Issue Date: Jan-2021
Publisher: NISCAIR-CSIR, India
Abstract: Series of N'-(pyridine-3-ylmethylene)benzohydrazides 3a-y have been prepared by the condensation of nicotinaldehydes 1a-e with benzohydrazides 2a-e in the presence of glacial AcOH in ethanol at room temperature. Total twenty five compounds have been prepared and confirmed based on spectral data. The compounds have been evaluated for anti-microbial, free radical scavenging (DPPH, ABTS.+) and α-glucosidase inhibitory activities. Compound 3h has shown potent anti-fungal activity. Compounds 3f-g and 3j have shown potent ABTS.+ free radical scavenging activity. Compound 3d has shown potent anti-hyperglycemic activity.
Page(s): 117-126
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.60B(01) [January 2021]

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