Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/5590
Title: Isolation and characterization of recombinant <i style="">Brugian</i> parasitic transglutaminase
Authors: Uma, V
Geetha, M
Murugan, V
Kaliraj, P
Keywords: adjuvants
filaricidals
immunoprophylaxis
molting
nematodes
protein disulphide isomerase
transgluta-minase
vaccine
Issue Date: Jul-2006
Publisher: CSIR
Series/Report no.: Int. Cl.<sup>8</sup> C12N9/64
Abstract: An attempt has been made to identify and characterize a putative chemotherapeutic target antigen for human lymphatic filariasis by recombinant DNA techniques. Identification of transglutaminase (TGA), an enzyme vital for the growth and survival of the parasites, has opened a new drug target for developing potent therapeutic agents against the parasites. TGA gene from <i style="">Brugia malayi</i> adult female parasite (BmTGA) has been subcloned, expressed and purified as a 47 kDa fusion protein with N-terminal histidine tag. Since BmTGA lacks homology to mammalian TGAs, it is a promising drug target for developing chemotherapeutic agent and candidate vaccine against human lymphatic filariasis.
Description: 317-326
URI: http://hdl.handle.net/123456789/5590
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.05(3) [July 2006]

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