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|Title:||Isolation and characterization of recombinant <i style="">Brugian</i> parasitic transglutaminase|
protein disulphide isomerase
|Series/Report no.:||Int. Cl.<sup>8</sup> C12N9/64|
|Abstract:||An attempt has been made to identify and characterize a putative chemotherapeutic target antigen for human lymphatic filariasis by recombinant DNA techniques. Identification of transglutaminase (TGA), an enzyme vital for the growth and survival of the parasites, has opened a new drug target for developing potent therapeutic agents against the parasites. TGA gene from <i style="">Brugia malayi</i> adult female parasite (BmTGA) has been subcloned, expressed and purified as a 47 kDa fusion protein with N-terminal histidine tag. Since BmTGA lacks homology to mammalian TGAs, it is a promising drug target for developing chemotherapeutic agent and candidate vaccine against human lymphatic filariasis.|
|ISSN:||0975-0967 (Online); 0972-5849 (Print)|
|Appears in Collections:||IJBT Vol.05(3) [July 2006]|
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