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Title: Isolation and characterization of recombinant Brugian parasitic transglutaminase
Authors: Uma, V
Geetha, M
Murugan, V
Kaliraj, P
Keywords: adjuvants;filaricidals;immunoprophylaxis;molting;nematodes;protein disulphide isomerase;transgluta-minase;vaccine
Issue Date: Jul-2006
Publisher: CSIR
IPC Code: Int. Cl.8 C12N9/64
Abstract: An attempt has been made to identify and characterize a putative chemotherapeutic target antigen for human lymphatic filariasis by recombinant DNA techniques. Identification of transglutaminase (TGA), an enzyme vital for the growth and survival of the parasites, has opened a new drug target for developing potent therapeutic agents against the parasites. TGA gene from Brugia malayi adult female parasite (BmTGA) has been subcloned, expressed and purified as a 47 kDa fusion protein with N-terminal histidine tag. Since BmTGA lacks homology to mammalian TGAs, it is a promising drug target for developing chemotherapeutic agent and candidate vaccine against human lymphatic filariasis.
Page(s): 317-326
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.05(3) [July 2006]

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