Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/55842
Title: Polyphenol rich extract from Sesbania grandiflora (L.) Pers. bark reduces rheumatism by mediating the expression of NF kappa B in rats
Authors: Arora, Sumit
Itankar, Prakash
Keywords: Agati;Antioxidant;Antirheumatic;Immunohistochemistry;NFκB;Vegetable Hummingbird
Issue Date: Jan-2021
Publisher: NISCAIR-CSIR, India
Abstract: Sesbania grandiflora (L.) Pers. (Fabaceae) commonly called Agati or Vegetable Hummingbird, is autochthonal from Malaysia to North Australia; plant is cultivated in several parts of India. Root and bark paste is applied externally to relive pain and inflammation associated with arthritis. It has long been used as a traditional medicine for rheumatism. Keeping this in cognizance, the study was designed to explore the antirheumatic potential of S. grandiflora. The bark extracts were prepared and studied for their phytochemical study, in vitro antioxidant potential using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) radicals and antiarthritic activity against Complete Freund Adjuvant (CFA) induced arthritis. To probe into the causal mechanism of action, NFκB suppressing activity in paraventricular nucleus (PVN) of hypothalamus using potent extract was also studied. Polyphenol rich extract supplementation significantly normalizes the altered blood parameters and reverses the increase in paw thickness, a sign of arthritis in rats. Further, immunohistochemical analysis revealed significant reduction in the NFκB immunoreactive cells in 50% methanolic extract treated (14 days) arthritic rats (57%; p<0.001) as compared to control. These results consolidate the observation, that inhibition of NFκB may be a beneficial approach in the treatment of arthritis. This study corroborates the traditional use of S. grandiflora plant in rheumatism.
Page(s): 44-53
URI: http://nopr.niscair.res.in/handle/123456789/55842
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.59(01) [January 2021]

Files in This Item:
File Description SizeFormat 
IJEB 59(1) 44-53.pdf501.02 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.