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dc.contributor.authorKar, P-
dc.contributor.authorDutta, S-
dc.contributor.authorChakraborty, A K-
dc.contributor.authorBhattacharya, M-
dc.contributor.authorSen, A-
dc.identifier.issn0975-1068 (Online); 0972-5938 (Print)-
dc.description.abstractAncient civilization to present-day cultural and technological development, human over the world has been using plants as a source of natural medicine for their basic needs. Clerodendrum serratum (Linn.) Moonis one such traditionally well-accepted plant used vigorously in Indian ayurvedic therapeutic purposes. Despite its ethnomedicinal significance, the neuroprotective prospects and relevance of Clerodendrum serratum (CSL) remain unaddressed. Therefore, in the present study, we explored several in-vivo antioxidant enzymatic assays followed by acetylcholinesterase enzyme (AChE) inhibitory activity against neurodegenerative disorders (NDs) in mice model and explore the beneficial impact of the plant extract. Furthermore, the in-silico molecular docking approach was employed to evaluate the inhibitory potential of the plant-derived bioactive compounds against the imperative proteins associated with neurodegenerative disorders. The plant extract showed promising results in all in-vivo enzymatic assays indicating its positive role over several neurodegenerative disseases namely, Alzheimer’s and Parkinson’s disease. The histological and in-silico investigation also reveled this plant extract is promising in elevating neurodegenerative disorders. Therefore, it seems likely that this plant can be used as an anti-cognitive agent for future drug development.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.ispartofseriesInt. Cl.20: A61K 38/00, A61K 8/49, B63C 1/04, A61K 38/00en_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJTK Vol.19(4) [October 2020]en_US
dc.subjectClerodendrum serratumen_US
dc.subjectMolecular dockingen_US
dc.titleLeaf extract of ethnomedicinally important Bharangi (Clerodendrum serratum) may improve neuromodulatory activity in mice modelen_US
Appears in Collections:IJTK Vol.19(4) [October 2020]

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