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Title: P2O5-mediated Friedel-Crafts acylation of activated arenes with carboxylic acid as acylating agent
Authors: Kalshetti, Rupali G
Mandle, Ram D
Kamble, Sanjay P
Sudalai, Arumugam
Keywords: Friedel-Crafts acylations;Phosphorus pentoxide;Carboxylic acid;4-methoxyacetophenone
Issue Date: Dec-2020
Publisher: NISCAIR-CSIR, India
Abstract: P2O5 has been found to be a highly efficient and environmental friendly catalyst for the liquid-phase acylation of activated aromatic substrates giving aromatic ketones (45-93%) in a regioselective manner. Both aromatic and aliphatic carboxylic acids can be employed as acylating source. The process is particularly demonstrated at 100 g scale in the case of anisole and acetic acid to produce 4-methoxyacetophenone.
Page(s): 1861-1867
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(12) December 2020]

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