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dc.contributor.authorNandi, Sisir-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractGrowing attention has been focussed towards a considerable amount of experimental and theoretical study of anti toxoplasmosis compounds having inhibitory activities against toxoplasmosis. Toxoplasmosis is a dangerous disease in both urban as well as rural areas. It is caused by Toxoplasma gondii. The life cycle involves feline species such as both domestic and wild cats, and other felids such as lions, etc. There are various targets for developing anti toxoplasmosis agents. One of the most promising targets is dihydrofolate reductase (DHFR). 1,3,5-Triazine compounds have been reported to inhibit the T. gondii. But there is hardly any formulation of quantitative structure-activity relationship (QSAR) involving 1,3,5-triazine inhibitors to date. Therefore, it is our target in the present study to develop QSAR models based on the computed theoretical molecular descriptors to scale the essential features responsible for the DHFR inhibition. These screened features of the selected compounds will help to design the potent congeneric series.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.59B(12) December 2020]en_US
dc.subjectToxoplasma gondiien_US
dc.subject1,3,5-triazine compoundsen_US
dc.subjectCalculated theoretical molecular descriptorsen_US
dc.subjectQSAR modelingen_US
dc.titleQSAR of 1,3,5-triazine compounds towards inhibition of toxoplasmosis utilizing computed molecular descriptorsen_US
Appears in Collections:IJC-B Vol.59B(12) December 2020]

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