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dc.contributor.authorSridevi, N-
dc.contributor.authorMadheswari, D-
dc.identifier.issn0975-0975(Online); 0376-4710(Print)-
dc.description.abstractNovel tri-dentate ligand-metal complexes [Mn(II), Co(II), Cu(II), Ni(II) and Zn(II) (1-5)] have been synthesized using L-histidine amino acid derived Schiff base ligand and characterized using analytical and spectral methods like UV-visible, FT-IR and ESI-MS techniques. The antioxidant studies of the Schiff base ligand and 1-5 complexes reveal that complexes exhibit significant free radical scavenging activity against the free radical DPPH. In vitro cytotoxic activity of the 1-5 complexes evaluated against the breast cancer cell lines (MCF-7), reveal that complex 3 exhibits higher cytotoxicity than any other synthesized metal complexes. The docking studies have been carried out using BSA protein and DNA biomolecules with synthesized metal complexes. Antimicrobial studies has demonstrated that Cu(II) complexes possess higher activity against both Gram positive and Gram negative bacteria as well as Fungi.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-A Vol.59A(12) [December 2020]en_US
dc.subjectAmino acid Schiff baseen_US
dc.subjectHistidine biomoleculeen_US
dc.subjectMetal complexesen_US
dc.subjectAnticancer activityen_US
dc.subjectDocking studiesen_US
dc.subjectAntimicrobial activityen_US
dc.titleTheoretical and experimental studies of novel histidine derived Schiff base metal complexes, active towards biomedical and MCF 7 cell linesen_US
Appears in Collections:IJC-A Vol.59A(12) [December 2020]

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