Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/55667
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dc.contributor.authorRay, Partho Sarothi-
dc.contributor.authorGoswami, Binita-
dc.date.accessioned2020-11-23T07:14:57Z-
dc.date.available2020-11-23T07:14:57Z-
dc.date.issued2020-12-
dc.identifier.issn0975-0959 (Online); 0301-1208 (Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/55667-
dc.description662-669en_US
dc.description.abstractCOVID-19, the multifactorial disease caused by the novel coronavirus SARS-CoV-2 is mediated by specific antiviral and inflammatory responses. It is now recognized that in most severe cases of COVID-19 an excessive and uncontrolled inflammatory response exacerbates lung damage caused by viral infection, and contributes to acute respiratory distress syndrome and respiratory failure. This hyperinflammatory syndrome is characterized by multiple cellular and molecular events, including aberrant neutrophil and lymphocyte function, amplification of the inflammatory response by release of damage associated molecular patterns, cytokine storm, lung damage and edema and a pro-fibrotic condition, ultimately leading to respiratory failure. This review discusses these molecular events in correlation with stages of viral infection and disease progression, underscoring the key points that characterize the clinical manifestations of the hyperinflammatory syndrome in COVID-19. Furthermore, it discusses the available or potential therapeutics that target various important mediators of this hyperinflammatory response that are being considered for treatment of COVID-19.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJBB Vol.57(6) [December 2020]en_US
dc.subjectChemokineen_US
dc.subjectCytokine stormen_US
dc.subjectLung injuryen_US
dc.subjectLymphohistiocytosisen_US
dc.subjectNeutrophilen_US
dc.titleCOVID-19 and Hyperinflammatory Syndromeen_US
dc.typeArticleen_US
Appears in Collections:IJBB Vol.57(6) [December 2020]

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