NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biotechnology (IJBT) >
IJBT Vol.05 [2006] >
IJBT Vol.05(1) [January 2006] >


Title: Immune responses to inactivated oil adjuvanted Equine Herpes Virus-1 using different emulsifiers in horses
Authors: Singh, B K
Tandon, S N
Virmani, N
Keywords: booster effect
CFT
EHV-1 immunogen
emulsifiers
horses
immunization
VNT
Issue Date: Jan-2006
Publisher: CSIR
IPC CodeInt. Cl.7 A61K39/27
Abstract: Immune responses to formalin inactivated, oil adjuvanted equine herpes virus-1 (EHV-1) using Tween-80 (OET-80) and mannide monooleate (OEMM) emulsifiers were compared with a killed EHV-1 commercial vaccine in the three groups of EHV-1 seronegative Kathiawari horses. Each group of horses (n=3) was immunized with three doses each of the OET-80, OEMM and commercial vaccine. The complement fixation test (CFT) and virus neutralization test (VNT) were used to measure antibody levels in these horses. Mild complement-fixing (CF) antibody responses were observed after primary immunization with all the three products. Nearly 4-fold rise in CF antibody response after first booster in horses was seen up to 5, 6 and 9 weeks with OET-80, commercial vaccine and OEMM, respectively. Second booster CF antibody response was also seen in all the three groups. After primary immunization, VN antibody response was noticed in all the three groups. However, first booster injection of commercial vaccine, OET-80 and OEMM increased nearly 4-fold rise in VN antibody titre; which lasted up to 7, 9, and 12 weeks, respectively. VN antibody titre obtained after first booster injection of OEMM in horses was significantly higher (P≤0.05) as compared to OET-80 and commercial vaccine. After second booster injection rise in VN antibody titre was also observed in all the three groups of immunized horses. Control group of horses did not show any CF and VN antibodies responses. OEMM produced better CF and VN antibody responses than OET-80 and commercial vaccine.
Page(s): 42-46
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Source:IJBT Vol.05(1) [January 2006]

Files in This Item:

File Description SizeFormat
IJBT 5(1) 42-46.pdf97.19 kBAdobe PDFView/Open
 Current Page Visits: 478 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 559857 since 06-Feb-2009  Last updated on 30-Jul-2014Webmaster: nopr@niscair.res.in