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Title: Enantioselective bioreduction of heptan-2-one and octan-2-one catalyzed by Daucus carota cells
Authors: Chanysheva, Aliya R
Zorin, Vladimir V
Keywords: Daucus carota;Bioreduction;Exogenous reducing agents;(2S)-(+)-heptan-2-ol;(2S)-(+)-octan-2-ol
Issue Date: Sep-2020
Publisher: NISCAIR-CSIR, India
Abstract: Synthesis of enantiomerically pure (2S)-(+)-heptan-2-ol and (2S)-(+)-octan-2-ol by bioreduction of heptan-2-one and octan-2-one using Daucus carota cells has been studied. Optimization of bioreduction conditions has been carried out in the presence of various exogenous reducing agents (ethanol, isopropanol, glucose). Conditions allowing to obtain (2S)-(+)-heptan-2-ol with 91% yield and optical purity 98% ee and (2S)-(+)-octan-2-ol in 95% yield and > 99% ee have been found.
Page(s): 1381-1383
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(09) [September 2020]

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