Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/55441
Title: An efficient regioselective synthesis of N-alkylated purine-triazole analogues
Authors: Pandit, Chintan
Pandya, Mayank
Jadeja, Yashwantsinh
Gohel, Jyoti
Kapadiya, Khushal
Keywords: 2,6-Dichloropurine;Triazoles;Regioselectivity
Issue Date: Aug-2020
Publisher: NISCAIR-CSIR, India
Abstract: Nitrogen rich purine adduct (2) was prepared by reaction of 2,6-dichloro purine (1) with hydrazine hydrate was converted to hybrid purine-triazole ring (4) by a simple cyclisation process (con. HCl & methanol) on reaction with 3-phenoxy benzaldehyde. The regioselectivity of synthesized adducts was carried out by simple spectroscopic techniques i.e. IR, 1H NMR & 13C NMR spectra. These studies gave an idea regarding replacement of chlorine out of C-2 or C-6 position. Novelty was introduced by alkyl substation at N-9 position of imidazole ring and at –NH of triazole ring and a series of 4-chloro-5a,6-dihydro-1,6-dialkylated-8-(3-phenoxyphenyl)-1H-[1,2,4]triazolo[3,4-e]purine (5a-5g) hybrids were synthesized.
Page(s): 1225-1233
URI: http://nopr.niscair.res.in/handle/123456789/55441
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(08) [August 2020]

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IJCB 59B(8) 1225-1233.pdfMain Article230.4 kBAdobe PDFView/Open
IJCB 59B(8) 1225-1233_Suppl Data_1.pdfSupplementary Data 1301.59 kBAdobe PDFView/Open
IJCB 59B(8) 1225-1233_Suppl Data_2.pdfSupplementary Data 2100.56 kBAdobe PDFView/Open
IJCB 59B(8) 1225-1233_Suppl Data_3.pdfSupplementary Data 3302.8 kBAdobe PDFView/Open
IJCB 59B(8) 1225-1233_Suppl Data_4.pdfSupplementary Data 4377.57 kBAdobe PDFView/Open
IJCB 59B(8) 1225-1233_Suppl Data_5.pdfSupplementary Data 5274.4 kBAdobe PDFView/Open
IJCB 59B(8) 1225-1233_Suppl Data_6.pdfSupplementary Data 61.61 MBAdobe PDFView/Open
IJCB 59B(8) 1225-1233_Suppl Data_7.pdfSupplementary Data 7214.05 kBAdobe PDFView/Open
IJCB 59B(8) 1225-1233_Suppl Data_8.pdfSupplementary Data 875.46 kBAdobe PDFView/Open
IJCB 59B(8) 1225-1233_Suppl Data_9.pdfSupplementary Data 9400.64 kBAdobe PDFView/Open


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