Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/55438
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWalmik, Prabhaker-
dc.date.accessioned2020-10-05T08:58:43Z-
dc.date.available2020-10-05T08:58:43Z-
dc.date.issued2020-08-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/55438-
dc.description1191-1198en_US
dc.description.abstractThe present study anticipates the development of novel antioxidant, antimicrobial and antitubercular drugs by using the indole scaffold. Novel indole derivatives, (4a-c), (5a-c) and (6a-i) have been prepared. The structures of all these unknown compounds have been confirmed with the help of elemental analysis, IR, 1H & 13C NMR and mass spectral data. All these previously unknown synthesized compounds screened for their antioxidant, antimicrobial and antitubercular activities. Compound 5a exhibited good RSA 76.58 %, IC50 value <25 µg/mL. Compound 5a exhibited higher absorbance 0.691nm, at concentration 100 µg/mL. Compound 6a showed good metal chelating activity (64.10 %) at a concentration 100 µg/mL. Compound 6a showed potent activity against S. aureus and P. aeruginosa. Compounds 4a and 5a showed promising antitubercular activity MIC 6.25 µg/mL. Compound 6a showed excellent activity (MIC= 3.125 µg/mL) against M. tuberculosis H37Rv, than the standards pyrazinamide (MIC= 3.125) and Streptomycin (6.25 µg/mL).en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.59B(08) [August 2020]en_US
dc.subjectIndoleen_US
dc.subjectDihydropyridineen_US
dc.subjectDihydro[1,2,4]triazol[1,5]pyridineen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectAntitubercular activityen_US
dc.titleSynthesis and biological evaluation of novel indolyl-dihydropyridin-3-carboxylate, dihydro[1,2,4]triazol[1,5]pyridin-3-carboxylate and carbohydrazide derivativesen_US
dc.typeArticleen_US
Appears in Collections:IJC-B Vol.59B(08) [August 2020]

Files in This Item:
File Description SizeFormat 
IJCB 59B(8) 1191-1198.pdf458.1 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.