Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/55370
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dc.contributor.authorSönmez, Pınar Kılıçaslan-
dc.contributor.authorTurhan, Ali-
dc.contributor.authorÖztatlıcı, Mustafa-
dc.contributor.authorÖzbilgin, Kemal-
dc.date.accessioned2020-09-30T05:46:13Z-
dc.date.available2020-09-30T05:46:13Z-
dc.date.issued2020-10-
dc.identifier.issn0975-0959 (Online); 0301-1208 (Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/55370-
dc.description560-566en_US
dc.description.abstractPhotodynamic therapy works with a photosensitizer that is stimulated when exposed to a light source of a specific wavelength and produces a form of oxygen that can be used in cancer treatments. In this study, we investigated the effect of laser on apoptosis on breast cancer cell lines (MDA-MB-231) treated with verteporfin in cell culture media. Verteporfin added MDA-MB-231 cells were incubated without light for 24 hours after applying laser light at a wavelength of 695 nm at an intensity of 50 J/cm2 at various times. Anti-proliferative effects were evaluated by immunoreactivity of anti-Bcl-2 and anti-Bax antibodies by immunocytochemical staining. When anti-Bax/Anti-Bcl-2 ratio are compared, the ratio of 1.5 in the control group cells decreases in short-term laser applications, while it approaches normal values in the 7th min after long-term laser application and reaches a very high value in the 9th min. Therefore, our results suggest that verteporfin-mediated PDT may be a potential combined therapy strategy against breast carcinoma by increasing apoptosis.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJBB Vol.57(5) [October 2020]en_US
dc.subjectBaxen_US
dc.subjectBcl-2en_US
dc.subjectLaseren_US
dc.subjectMDA-MB-231en_US
dc.subjectPhotosensitizeren_US
dc.titleEffects of verteporfin-mediated photodynamic therapy in breast cancer cellsen_US
dc.typeArticleen_US
Appears in Collections:IJBB Vol.57(5) [October 2020]

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