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IJEB Vol.45(05) [May 2007] >


Title: Effect of simvastatin on fracture healing—An experimental study
Authors: Saraf, S K
Singh, Ajit
Garbyal, R S
Singh, Vakil
Keywords: Anti-resorptive factor
Fracture healing
Growth factors
Statin
Issue Date: May-2007
Publisher: CSIR
Abstract: Left femur was osteotomized and fixed with K wire in 21 rabbits. One group was fed simvastatin (120 mg/kg body wt/day) orally, whereas another group without medication served as control. Both groups were assessed radiologically, morphologically, histologically and biomechanically at 4, 8 and 12 weeks. An analysis of various parameters of study showed that simvastatin treated group had improved bone healing at 4 and 8 weeks of follow up, however, the difference was not significant statistically at 12 weeks. So it is concluded that Simvastatin favourably hastened the process of fracture healing in the rabbits at earlier phases.
Page(s): 444-449
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(05) [May 2007]

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