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Title: Neuroprotective evaluation of standardized extract of Centella asciatica in monosodium glutamate treated rats
Authors: Ramanathan, M
Sivakumar, S
Anandvijayakumar, P R
Saravanababu, C
Pandian, P Rathinavel
Keywords: Centella asiatica;Dextromethorphan;Excitotoxicity;Gabapentine;Monosodiumglutamate;Neurodegeneration
Issue Date: May-2007
Publisher: CSIR
Abstract: The effect of chloroform: methanolic (80:20) extract of C. asiatica (CA; 100 and 200mg/kg), was evaluated on the course of free radical generation and excitotoxicity in monosodiumglutamate (MSG) treated female Sprague Dawley rats. The extract showed significant improvement in catalase, super oxide desmutase and lipid peroxides levels in hippocampus and striatum regions. Glutathione level was not altered with CA treatment. Similar observation was made with dextromethorphan. The general behavior, locomotor activity and CA1 a region of the hippocampus was significantly protected by CA indicating neuroprotective effect of CA in MSG induced excitotoxic condition. Hence it can be concluded that CA protected MSG induced neurodegeneration attributed to its antioxidant and behavioural properties. This activity of CA can be explored in epilepsy, stroke and other degenerative conditions in which the role of glutamate is known to play vital role in the pathogenesis.
Page(s): 425-431
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.45(05) [May 2007]

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