Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/55185
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMohan, Mahalaxmi-
dc.contributor.authorBelapurkar, Pooja-
dc.contributor.authorMore, Sonal-
dc.contributor.authorPatil, Gaurav-
dc.date.accessioned2020-09-22T05:32:07Z-
dc.date.available2020-09-22T05:32:07Z-
dc.date.issued2020-06-
dc.identifier.issn0976-0512 (Online); 0976-0504 (Print)-
dc.identifier.urihttp://nopr.niscair.res.in/handle/123456789/55185-
dc.description79-88en_US
dc.description.abstractSolanum torvum Swartz is a well-known traditional herbal medicinal plant used in diabetes and diabetes-related complications. The objective of the study was to evaluate the effect of S. torvum on diabetic neuropathy in alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by using a single intraperitoneal injection of alloxan monohydrate (150 mg/kg; i.p.). After confirmation of diabetes, rats received metformin (120 mg/kg, p.o.) and STME (30 and 100 mg/kg, p.o) for 5 weeks. Diabetic rats showed significant (P <0.05) behavioural changes, increase in blood glucose levels, decrease in relative organ weight of pancreas, significant (P <0.05) decrease in reduced glutathione (RGSH) and significant (P <0.05) increase in TBARS levels. While STME (100 mg/kg) treated diabetic rats significantly (P <0.05) reversed the above parameters as compared to diabetic rats. Treatment with STME (100 mg/kg) has also reversed histopathological changes as observed in diabetic control rats. The study suggests that methanolic extract of S. torvum ameliorates diabetic neuropathy in alloxan-induced diabetic rats.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.ispartofseriesInt. cl. (2015.01)- A61K 36/00, A61K 36/81, A61K 131/00, A61P 3/00en_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJNPR Vol.11(2) [June 2020]en_US
dc.subjectAlloxan monohydrateen_US
dc.subjectDiabetic neuropathyen_US
dc.subjectMetforminen_US
dc.subjectSolanum torvumen_US
dc.titleEffect of Solanum torvum Swartz on diabetic neuropathy in alloxan-induced diabetic ratsen_US
dc.typeArticleen_US
Appears in Collections:IJNPR Vol.11(2) [June 2020]

Files in This Item:
File Description SizeFormat 
IJNPR 11(2) 79-88.pdf632.22 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.