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Title: Effect of Solanum torvum Swartz on diabetic neuropathy in alloxan-induced diabetic rats
Authors: Mohan, Mahalaxmi
Belapurkar, Pooja
More, Sonal
Patil, Gaurav
Keywords: Alloxan monohydrate;Diabetic neuropathy;Metformin;Solanum torvum
Issue Date: Jun-2020
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2015.01)- A61K 36/00, A61K 36/81, A61K 131/00, A61P 3/00
Abstract: Solanum torvum Swartz is a well-known traditional herbal medicinal plant used in diabetes and diabetes-related complications. The objective of the study was to evaluate the effect of S. torvum on diabetic neuropathy in alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by using a single intraperitoneal injection of alloxan monohydrate (150 mg/kg; i.p.). After confirmation of diabetes, rats received metformin (120 mg/kg, p.o.) and STME (30 and 100 mg/kg, p.o) for 5 weeks. Diabetic rats showed significant (P <0.05) behavioural changes, increase in blood glucose levels, decrease in relative organ weight of pancreas, significant (P <0.05) decrease in reduced glutathione (RGSH) and significant (P <0.05) increase in TBARS levels. While STME (100 mg/kg) treated diabetic rats significantly (P <0.05) reversed the above parameters as compared to diabetic rats. Treatment with STME (100 mg/kg) has also reversed histopathological changes as observed in diabetic control rats. The study suggests that methanolic extract of S. torvum ameliorates diabetic neuropathy in alloxan-induced diabetic rats.
Page(s): 79-88
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.11(2) [June 2020]

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