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Title: Condensation of nicotinaldehydes with phenylethanones: A convenient synthesis and biological activities of chalcones #
Authors: Ramya, S
Teja, K Sai
Hariprasad, K S
Praveena, G
Zehra, A
Tiwari, A K
Prakasham, R S
Raju, B China
Keywords: Nicotinaldehydes;Chalcones;Anti-microbial activity;α-glucosidase inhibitory activity
Issue Date: Jul-2020
Publisher: NISCAIR-CSIR, India
Abstract: Claisen-Schmidt condensation of nicotinaldehydes 1a-e with various phenylethanones 2a-d in the presence of base at room temperature have provided chalcones 3a-t. All the synthesized compounds have been evaluated for their anti-microbial, free-radical scavenging and α-glucosidase inhibitory activities. Compounds 3d and 3h have been identified as potent anti-fungal and moderate anti-bacterial agents. Compounds 3c, 3h, 3k-m and 3q have shown α-glucosidase inhibitory activity.
Page(s): 991-1000
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(07) [July 2020]

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