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Title: Condensation of nicotinaldehydes with acetophenones and NH4OAc: A convenient synthesis and biological activities of 2',6'-diphenyl-3,4'-bipyridines #
Authors: Begum, Shahnaz
Rajeswari, B Uma
Zehra, A
Tiwari, A K
Prakasham, R S
Raju, B China
Keywords: Nicotinaldehydes;2',6'-diphenyl-3,4'-bipyridines;Anti-microbial activity;α-glucosidase inhibitory activity
Issue Date: Jul-2020
Publisher: NISCAIR-CSIR, India
Abstract: 2',6'-Diphenyl-3,4'-bipyridines 3a-t have been achieved by the three-component, one-pot reaction of nicotinaldehydes 1a-b, acetophenones 2a-j and anhydrous ammonium acetate under solvent free conditions at 120°C. All the prepared compounds 3a-t have been screened for anti-microbial, free-radical scavenging and α-glucosidase inhibitory activities. Compounds 3m-r have shown anti-bacterial activity and compounds 3m-n identified as anti-fungal agents. Compounds 3d, 3h, 3m and 3r-s have shown α-glucosidase inhibitory activity.
Page(s): 1001-1009
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(07) [July 2020]

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