Please use this identifier to cite or link to this item:
Title: CuI-NPs catalyzed mechanochemical-assisted N-Boc protection of organic amines
Authors: Kantharaju, K
Hiremath, Prashant B
Keywords: Amine protection;CuI-NPs;Nanocatalysis;Mechanochemical;N-Boc protected amine
Issue Date: Jul-2020
Publisher: NISCAIR-CSIR, India
Abstract: A simple, solvent-free, faster and mechanochemical approach for the N-tert-butoxycarbonylation of amines catalyzed by copper iodide nanoparticles as a recyclable catalyst is described. The advantages of this method are simplicity, shorter reaction time (5–15 min), a cost-effective catalyst, and excellent product isolation (82-92%). N-Boc protection of various structurally diverse aliphatic, aromatic, and heterocyclic amines have been carried out with (Boc)2O with 10 mol% catalyst under pestle mortar grinding under solvent-free conditions. The catalyst possesses distinct advantages, ease of handling as well as removal, cleaner reactions, high activity, and environmentally benign. The final product has been characterised by various spectroscopic techniques.
Page(s): 1016-1024
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(07) [July 2020]

Files in This Item:
File Description SizeFormat 
IJCB 59B(7) 1016-1024.pdfMain Article454.37 kBAdobe PDFView/Open
IJCB 59B(7) 1016-1024_Suppl Data.pdfSupplementary Data789.71 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.