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Title: An eco-safe and solvent-free approach for clean and one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives using Zn(OAc)2.2H2O as an environmental friendly, readily and efficient catalyst
Authors: Mohamadpour, Farzaneh
Keywords: 3,4-Dihydropyrimidin-2-(1H)-ones/thiones derivatives;Zinc acetate dihydrate (Zn(OAc)2.2H2O);Biginelli condensation reaction;Solvent-free conditions;Environment friendly;Economical synthesis
Issue Date: Jul-2020
Publisher: NISCAIR-CSIR, India
Abstract: An environmental friendly, economical and clean Biginelli approach in presence of readily available zinc acetate dihydrate (Zn(OAc)2.2H2O) to access biologically active 3,4-dihydropyrimidin-2-(1H)-ones/thiones derivatives via one-pot, three-component reaction of β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea in high to excellent yields has been studied. This solvent-free procedure is sustainable and advantageous compared to conventional methods due to short reaction times, one-pot procedure, easy handling, efficient, environmentally benign nature, low-cost and non-toxic catalyst, eco-friendly, ready availability of starting materials and no requirement of chromatographic purification. The products have been characterized by melting points and 1H NMR spectroscopy.
Page(s): 1030-1038
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(07) [July 2020]

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