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Title: Synthesis and biological evaluation of novel phosphonyl thiazolo pyrazoles
Authors: Srinivas, Avula
Sunitha, Malladi
Karthik, Pulluri
Reddy, K Vasumathi
Keywords: Phosponylpyrazoles;Bestmenohira reagent;Click reaction;Knovenagel condensation;Cyclisation;Nematicidal activity
Issue Date: Jun-2020
Publisher: NISCAIR-CSIR, India
Abstract: A series of novel dimethyl 7-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-4-(4-fluorophenyl)-9-oxo-8-phenyl-6-thia-1,2,8-triazaspiro[4.4]non-2-en-3-ylphosphonate 11a-g have been synthesized by the reaction of chalcone derivatives of (E)-5-benzylidene-2-((2S,3S)-3-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2H-pyran-2-yl)-3-phenylthiazolidin-4-one 10a-g with Bestmen Ohira reagent. The chemical structures of newly synthesized compounds have been elucidated by IR, NMR, MS and elemental analysis. The compounds 11a-g have been evaluated for their nematicidal activity against Dietylenchus myceliophagus and Caenorhabditis elegans. Compound 11b, 11c, 11g and 11f show appreciable nematicidal activity.
Page(s): 867-876
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(06) [June 2020]

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