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Title: Association of Lipid biomarkers with drinking patterns and severity in alcoholic liver disease - A hospital- based cross- sectional study
Authors: Anithasri, Anbalagan
Arulvijayavani, Subramaniam
Gopinath, Poonguzhali
Varuni, Annamalai Kumarasamy
Keywords: Alcoholic Liver Disease;AUDIT score;Child Pugh’s score;Dyslipidemia;Lipid Profile
Issue Date: Aug-2020
Publisher: NISCAIR-CSIR, India
Abstract: Alcoholic liver disease (ALD) is one of the leading causes of death due to cirrhosis. Dyslipidemia is a common finding in  ALD  and  lipid  parameters  are  shown  to  be  associated  with  disease  severity.  However  the  effect  of  alcohol  drinking pattern on lipid abnormalities is still unclear. Hence this cross sectional study was planned to estimate the serum lipid profile in ALD patients and to determine the association of lipid parameters with alcohol drinking pattern and the severity of liver disease.50  male  patients  with  ALD  and  50  age  matched  controls  were  enrolled.  AUDIT  score  was  used  to  assess  their drinking pattern. Serum lipid profile and liver parameters were estimated and compared between the cases and controls. The patients  were  grouped  based  on  severity  into  Child  Pugh's  group  A,  B  and  C  and  the  study  parameters  were  compared between the groups. All statistical analyses were done using SPSS v20.0. The mean total cholesterol level (126.98±45.06 vs 163.2±24.38 mg/dL), LDL and HDL cholesterol was significantly less in ALD compared to controls. Total cholesterol and LDL cholesterol levels were low in Child Pugh's Score C group. Mean AUDIT score was18 ± 4. Low Total cholesterol and  LDL  cholesterol  levels  correlate  with  disease  severity  and  are  markers  of  poor  prognosis.  Lipid  parameters  do  not correlate with alcohol drinking patterns in ALD.
Page(s): 395-400
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.57(4) [August 2020]

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