Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/54689
Title: Microwave assisted template synthesis of metal based EGFR, TRK inhibitors, molecular docking and in vitro biological studies
Authors: Jain, Preeti
Singh, Vandna
Tripathi, Vishwas
Keywords: Antioxidant;EGFR;Microwave method;Molecular docking;Template synthesis
Issue Date: Jun-2020
Publisher: NISCAIR-CSIR, India
Abstract: Metal based biologically active compounds have been synthesized by microwave assisted template condensation method and characterized by spectro-analytical techniques like molar conductance, UV-visible, infrared and mass spectroscopy and thermogravimetric analysis. The metal is arranged in octahedral geometry surrounded by tetradentate ligand framework. The binding affinity of all the metal complexes has been evaluated theoretically by molecular docking studies against epidermal growth factor receptor (EGFR) and tyrosine kinase (TRK) receptor molecules which are further verified by in vitro anticancer activity. Complex [Cr(C16H11N4O2)(NO3)2]NO3 have showed potent in vitro cytotoxicity (IC50 value 39.5μM) against SCC4 cancer cell line. Antioxidant study has also performed by DPPH assay and significant results are found.[Fe(C16H11N4O2)(OAc)2]OAc and [Cr(C16H11N4O2) (OAc)2]OAc are most effective antioxidants with 78.7% and 76.8% free radical scavenging activity, respectively.
Page(s): 752-759
URI: http://nopr.niscair.res.in/handle/123456789/54689
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.59A(06) [June 2020]

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