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|Title:||Facile synthesis and characterization of some new 5-arylidene-thiazolidine-2,4-diones and their antimicrobial evaluation|
|Keywords:||Alum;Antimicrobial evaluation;5-arylidene-thiazolidine-2,4-diones;Knovenagel condensation|
|Abstract:||A series of novel 5-arylidene-thiazolidine-2,4-diones derivatives have been synthesized by the Knoevenagel condensation of aromatic aldehydes and N-substituted thiazolidinedione-2,4-diones. Use of KAl(SO4)2•12(H2O) i.e. Alum for the reaction makes this synthesis facile because of several advantageous factors viz. non-toxicity, efficient catalytic ability and cheap cost of alum. Substitution of arylidene moiety at the position 5 on the thiazolidine-2,4-diones nucleus has occured using this facile approach. Synthesized derivatives have been characterized using various analytical tools and antimicrobial evaluation thereof has been performed against Gram-positive, Gram negative bacteria and a fungal strain. All synthesized compounds show moderate to very good activity against the microorganisms that they have been tested against.|
|Appears in Collections:||IJC-B Vol.59B(05) [May 2020]|
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