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Title: A one pot, efficient and eco-friendly synthesis of 1,3,4-thiadiazolo[3,2-a] pyrimidine scaffold via Aza–Michael addition and intramolecular cyclo-elimination reactions in poly ethylene glycol (PEG)
Authors: Ahmad, Akeel
Tiwari, Shailendra
Keywords: Substituted phenyl;1,3,4-thiadiazolo;Pyrimidine;Carboxylate;Carbonitrile;Antimicrobial activity;Fungicidal activity
Issue Date: May-2020
Publisher: NISCAIR-CSIR, India
Abstract: Potassium carbonate in poly (ethylene glycol-400) has been found to be a highly effective and efficient medium for the straight forward, convenient, one pot and green synthesis of ethyl 2-substituted phenyl-7-oxo-7H-[1,3,4]- thiadiazolo [3,2-a]- pyrimidine-6-corboxylate and -6-corbonitrile through intramolecular cyclo-elimination of Michael adducts formed between the reaction of 2-amino-5 substituted thiadiazoles with diethyl-2- (ethoxymethylene) malonate and ethyl-2- cyano-3-ethoxyacrylate respectively. The structures of all the new compounds have been elucidated using IR, 1H and 13C NMR, mass spectral data and elemental analyses.
Page(s): 724-729
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(05) [May 2020]

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