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|Title:||Synthesis and characterization of novel chelation-free Zn(II)-azole complexes: Evaluation of antibacterial, antioxidant and DNA binding activity|
|Authors:||Nandanwar, Sondavid K|
Borkar, Shweta B
Wijaya, Bryan Nathanael
Piad, Lei Lottice Anne
Tiara, Celine Sheila
Kim, Hak Jun
Tarte, Naresh H.
|Keywords:||Zn(II) complex;2-isopropylimidazole;2-methylbenzimidazole;2-methylbenzoxazole;DNA binding|
|Abstract:||Here, we synthesized novel chelation-free Zn(II)-complexes (1-3) [ZnCl2L2] of monodentate ligands with L = 2-isopropylimidazole (L1), 2-methylbenzimidazole (L2), and 2-methylbenzoxazole (L3) and evaluated their antibacterial, antioxidant and DNA binding activities. The chelation-free properties of these coordination complexes were confirmed by UV-visible spectroscopy, 1H NMR spectroscopy, single X-ray crystallography and elemental analysis. Complexes 1-3 exhibited substantial antibacterial activity against all antibiotic susceptible bacteria within a concentration range of 100-200 µg/ml while free ligands L1 and L2 exhibited weak antibacterial activity considerably concentration above 200 µg/ml. Also, both complexes 2 and 3 were twice more active against methicillin-resistant Staphylococcus aureus (MRSA) than complex 1. Furthermore, we found that complexes 1-3 showed DNA binding activity with E. coli plasmid DNA and calf thymus DNA, which may be a plausible mechanism for their antibacterial activity. We also investigated the antioxidant activity of complexes 1-3 and found that complex 2 exhibited potential antioxidant activity compared to complexes 1 and 3. All these results suggest that the chelation-free Zn(II)-complexes can be the future candidates for more advance biological studies.|
|Appears in Collections:||IJC-A Vol.59A(05) [May 2020]|
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