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Title: Synthesis and characterization of novel chelation-free Zn(II)-azole complexes: Evaluation of antibacterial, antioxidant and DNA binding activity
Authors: Nandanwar, Sondavid K
Borkar, Shweta B
Wijaya, Bryan Nathanael
Bayarra, Enkhnaran
Piad, Lei Lottice Anne
Jin, QiuLi
Tiara, Celine Sheila
Kim, Hak Jun
Tarte, Naresh H.
Keywords: Zn(II) complex;2-isopropylimidazole;2-methylbenzimidazole;2-methylbenzoxazole;DNA binding
Issue Date: May-2020
Publisher: NISCAIR-CSIR, India
Abstract: Here, we synthesized novel chelation-free Zn(II)-complexes (1-3) [ZnCl2L2] of monodentate ligands with L = 2-isopropylimidazole (L1), 2-methylbenzimidazole (L2), and 2-methylbenzoxazole (L3) and evaluated their antibacterial, antioxidant and DNA binding activities. The chelation-free properties of these coordination complexes were confirmed by UV-visible spectroscopy, 1H NMR spectroscopy, single X-ray crystallography and elemental analysis. Complexes 1-3 exhibited substantial antibacterial activity against all antibiotic susceptible bacteria within a concentration range of 100-200 µg/ml while free ligands L1 and L2 exhibited weak antibacterial activity considerably concentration above 200 µg/ml. Also, both complexes 2 and 3 were twice more active against methicillin-resistant Staphylococcus aureus (MRSA) than complex 1. Furthermore, we found that complexes 1-3 showed DNA binding activity with E. coli plasmid DNA and calf thymus DNA, which may be a plausible mechanism for their antibacterial activity. We also investigated the antioxidant activity of complexes 1-3 and found that complex 2 exhibited potential antioxidant activity compared to complexes 1 and 3. All these results suggest that the chelation-free Zn(II)-complexes can be the future candidates for more advance biological studies.
Page(s): 589-597
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.59A(05) [May 2020]

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