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Title: Phytochemical screening, anti-oxidant and anti-inflammatory activities of ethyl acetate extract of Combretum punctatum var. squamosum
Authors: Thanzami, K.
Pachuau, V.L. Thatpuii
Lalremruati, C.
Kakoti, B.B.
Keywords: Anti-inflammatory;Anti-oxidant;Ethnomedicine;Leihruisen;Phytoconstituents
Issue Date: Mar-2020
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2015.01)- A61K 36/00, A61K 127/00, A61P 39/00
Abstract: The objective of this study was to carry out the phytochemical screening of the ethyl acetate extract of Combretum punctatum var. squamosum and to investigate anti-inflammatory and anti-oxidant activities. The phytochemical investigation indicated the presence of flavonoids and steroids in the extract. Anti-inflammatory activity was studied by in vitro inhibition of albumin denaturation and HRBC membrane stabilization methods; in vivo cotton pellet induced granuloma and carrageenan-induced paw oedema studies. The anti-oxidant activity was studied by lipid peroxidation and DPPH radical scavenging activity assays.The ethyl acetate extract at different concentrations showed a significant percent inhibition of albumin denaturation and percent inhibition of haemolysis when compared with the standard. The extract at 200 and 400 mg/kg b.w. significantly reduced cotton pellet granuloma (P <0.001) and carrageenan paw oedema (P <0.05) when compared with the standard in rats.The extract at different concentrations also showed a significant percent inhibition of lipid peroxidation and DPPH when compared with the standard.Thus, the result indicates that the ethyl acetate extract exhibited significantly good anti-inflammatory and anti-oxidant activities.
Page(s): 38-45
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.11(1) [March 2020]

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