Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/54473
Title: Clinico-Pathogenesis of COVID-19 in children
Authors: Pandit, Kaveri
Gupta, Shalu
Sharma, Ankita Goel
Keywords: Children;COVID-19;Disseminated Intravascular coagulation (DIC);Hyper-inflammatory State;SARS-CoV-2
Issue Date: Jun-2020
Publisher: NISCAIR-CSIR, India
Abstract: The recent pandemic by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causing Coronavirus disease-2019 (COVID-19) affects mainly adults and to a lesser extent children. The major route of spread is via droplets where the virus is released into the air in the form of droplets by an infected individual during coughing and sneezing. Virus primarily infects the respiratory tract epithelium. Its spike protein interacts via ACE-2 receptor and facilitates the entry of the virus into the cells by membrane fusion. The activated Cytotoxic T cells and other cells cause an exaggerated inflammatory response releasing huge amounts of pro-inflammatory cytokines like interleukins and interferon. Due to this surge in the cytokine levels leading to a storm like state, there is significant endothelial injury causing hyper-coaguable state and disseminated intravascular coagulation. The common presentation in children include involvement of respiratory system leading to pneumonia, severe pneumonia, acute respiratory distress syndrome and finally multiorgan involvement.
Page(s): 264-269
URI: http://nopr.niscair.res.in/handle/123456789/54473
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.57(3) [June 2020]

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