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http://nopr.niscair.res.in/handle/123456789/54454| Title: | Synthesis and interaction of thiazolo [2, 3-a] isoquinoline analog with DNA |
| Authors: | Ranade, Prasanna B Navale, Dinesh N Zote, Santosh W Ramana, M M V |
| Keywords: | N,N-Dicyclohexylcarbodiimide (DCC);Fluorescence;Static quenching;Circular dichroism |
| Issue Date: | Apr-2020 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A reaction between 1-(furan-2-yl)-3,4-dihydroisoquinoline and thioglycolic acid using N,N-Dicyclohexylcarbodiimide at 0−5 °C has given 10b-(furan-2-yl)-5,6-dihydro-2H-thiazolo[2,3-a]isoquinolin-3(10bH)-one [FUIQTGA]. The interaction between FUIQTGA and DNA has been studied using UV-visible spectroscopy, fluorescence and circular dichroism techniques. Static quenching mechanism is observed from fluorescence measurements of interaction between FUIQTGA and DNA. Circular dichroism reveals the minor groove binding mode between FUIQTGA and DNA. |
| Page(s): | 569-573 |
| URI: | http://nopr.niscair.res.in/handle/123456789/54454 |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Appears in Collections: | IJC-A Vol.59A(04) [April 2020] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCA 59A(4) 569-573.pdf | 427.42 kB | Adobe PDF | View/Open |
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