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Title: Synthesis and interaction of thiazolo [2, 3-a] isoquinoline analog with DNA
Authors: Ranade, Prasanna B
Navale, Dinesh N
Zote, Santosh W
Ramana, M M V
Keywords: N,N-Dicyclohexylcarbodiimide (DCC);Fluorescence;Static quenching;Circular dichroism
Issue Date: Apr-2020
Publisher: NISCAIR-CSIR, India
Abstract: A reaction between 1-(furan-2-yl)-3,4-dihydroisoquinoline and thioglycolic acid using N,N-Dicyclohexylcarbodiimide at 0−5 °C has given 10b-(furan-2-yl)-5,6-dihydro-2H-thiazolo[2,3-a]isoquinolin-3(10bH)-one [FUIQTGA]. The interaction between FUIQTGA and DNA has been studied using UV-visible spectroscopy, fluorescence and circular dichroism techniques. Static quenching mechanism is observed from fluorescence measurements of interaction between FUIQTGA and DNA. Circular dichroism reveals the minor groove binding mode between FUIQTGA and DNA.
Page(s): 569-573
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.59A(04) [April 2020]

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