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|Title:||Synthesis and characterization of new thiazole involving isatin for studying their antimicrobial activity|
Singh, Raj Bahadur
|Keywords:||Isatin;Thiazole;Schiff base;Mannich base;Formaldehyde;Secondary amine;Primary amine|
|Abstract:||1-(Substituted-1-ylmethyl)indoline-2,3-dione 1a-c have been synthesized from different types of secondary amine with isatin and formaldehyde in alcohol. The compound 1 have then been converted to the respective compound 2a-g (Z)3-(4-subsitutedphenylimino)-1-(substituted-1-ylmethyl)indolin-2-one by treatment with different types of primary amines. Interaction of compound 2 with thioglycolic acid and chloro acetyl chloride results in cyclization to give compound spiro isatin derivatives compounds 3a-g. The anti-microbial activity screening of novel spiro isatin substituted compounds have also been carried out.|
|Appears in Collections:||IJC-B Vol.59B(04) [April 2020]|
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