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Title: Synthesis and characterization of new thiazole involving isatin for studying their antimicrobial activity
Authors: Srivastava, Krishna
Lakhmani, Deepa
Srivasatava, Jyoti
Singh, Raj Bahadur
Keywords: Isatin;Thiazole;Schiff base;Mannich base;Formaldehyde;Secondary amine;Primary amine
Issue Date: Apr-2020
Publisher: NISCAIR-CSIR, India
Abstract: 1-(Substituted-1-ylmethyl)indoline-2,3-dione 1a-c have been synthesized from different types of secondary amine with isatin and formaldehyde in alcohol. The compound 1 have then been converted to the respective compound 2a-g (Z)3-(4-subsitutedphenylimino)-1-(substituted-1-ylmethyl)indolin-2-one by treatment with different types of primary amines. Interaction of compound 2 with thioglycolic acid and chloro acetyl chloride results in cyclization to give compound spiro isatin derivatives compounds 3a-g. The anti-microbial activity screening of novel spiro isatin substituted compounds have also been carried out.
Page(s): 485-487
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(04) [April 2020]

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