Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/54261
Title: Cytotoxic activity of extracts of demosponges Haliclona caerulea, Axinella sinoxea and Ircinia mutans from Persian Gulf
Authors: Nazemi, Melika
Ghaffari, Hadi
Moradi, Yazdan
Amiran, Mohammad Reza
Dargeri, Soheila Aghaei
Keywords: Anticancer activity;Lactate dehydrogenase assay;LDH leakage;Sponges;XTT assay
Issue Date: Apr-2020
Publisher: NISCAIR-CSIR, India
Abstract: Sponges are valuable source of bioactive natural products. Although marine benthic invertebrate communities occur in the Persian Gulf they have been little explored for their biomedicinal potential. Here, we studied the methanol and diethyl ether extracts of sponges Haliclona caeralea, Axinella sinoxea and Ircinia mutans sponges for their cytotoxic activity against human epidermis carcinoma (KB/C152) and T-cell lymphoma cell lines (HUT-78/C185) cell lines. Sponges after collection and identification were extracted with methanol and diethyl ether extract. The cell viability and cytotoxicity induced by the extracts were assessed using XTT and lactate dehydrogenase release assays (LDH leakage). The results indicated that the methanol and diethyl ether extract of I. mutans exhibited strong cytotoxicity towards KB and HUT cell lines and diethyl ether extract of H. caeralea and A. sinoxea had significant cytotoxicity in HUT and KB cells compared to methanol extract. The results indicated that the methanol and diethyl ether extract of I. mutanspossess significant cytotoxic activity.
Page(s): 249-253
URI: http://nopr.niscair.res.in/handle/123456789/54261
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.58(04) [April 2020]

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