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|Title:||Stereoselective synthesis of C1-C11 fragment of antitumor cyclodepsipeptide (–)-doliculide|
|Authors:||Suryachandra, Dargaiah Kummari|
Yadav, J S
|Keywords:||Depsipeptide;Enzymatic resolution;Marine natural products;Evan’s asymmetric methylation;Sharpless asymmetric epoxidation;Deoxypropionates|
|Abstract:||A general and stereoselective synthetic route for C1-C11 polyketide fragment of doliculide has been achieved in an efficient manner. The key reactions of our synthetic route are enzymatic desymmetrization of meso-diol, application of Evans auxiliary to introduce methyl group, Sharpless asymmetric epoxidation and substrate controlled nucleophilic addition reactions.|
|Appears in Collections:||IJC-B Vol.59B(03) [March 2020]|
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