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Title: Stereoselective synthesis of C1-C11 fragment of antitumor cyclodepsipeptide (–)-doliculide
Authors: Suryachandra, Dargaiah Kummari
Tenneti, Srinivasarao
Yadav, Nagendrananth
Yadav, J S
Keywords: Depsipeptide;Enzymatic resolution;Marine natural products;Evan’s asymmetric methylation;Sharpless asymmetric epoxidation;Deoxypropionates
Issue Date: Mar-2020
Publisher: NISCAIR-CSIR, India
Abstract: A general and stereoselective synthetic route for C1-C11 polyketide fragment of doliculide has been achieved in an efficient manner. The key reactions of our synthetic route are enzymatic desymmetrization of meso-diol, application of Evans auxiliary to introduce methyl group, Sharpless asymmetric epoxidation and substrate controlled nucleophilic addition reactions.
Page(s): 376-384
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(03) [March 2020]

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