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dc.contributor.authorKumar, B Senthil-
dc.contributor.authorMandle, Ram D-
dc.contributor.authorKamble, Sanjay P-
dc.contributor.authorSudalai, Arumugam-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractA short and straight-forward enantioselective synthesis of (R)-(+)-goniothalamin oxide 2 has been achieved with an overall yield of 39% and 99% ee. The synthetic approach involves l-prolinol catalyzed asymmetric epoxidation of cinnamaldehyde followed by Lewis acid-mediated diastereoselective allylation of epoxy aldehyde as the key chiral-inducing steps.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.59B(03) [March 2020]en_US
dc.subjectAsymmetric epoxidationen_US
dc.subject-prolinol catalysten_US
dc.subjectGrubbs’ catalysten_US
dc.subjectRing closing metathesisen_US
dc.titleA concise enantioselective synthesis of (R)-(+)-goniothalamin oxide, a trypanocidal active agent via L-prolinol catalyzed asymmetric epoxidation of cinnamaldehydeen_US
Appears in Collections:IJC-B Vol.59B(03) [March 2020]

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