Please use this identifier to cite or link to this item:
Title: A concise enantioselective synthesis of (R)-(+)-goniothalamin oxide, a trypanocidal active agent via L-prolinol catalyzed asymmetric epoxidation of cinnamaldehyde
Authors: Kumar, B Senthil
Mandle, Ram D
Kamble, Sanjay P
Sudalai, Arumugam
Keywords: Asymmetric epoxidation;Allylation;-prolinol catalyst;Esterification;Grubbs’ catalyst;Ring closing metathesis
Issue Date: Mar-2020
Publisher: NISCAIR-CSIR, India
Abstract: A short and straight-forward enantioselective synthesis of (R)-(+)-goniothalamin oxide 2 has been achieved with an overall yield of 39% and 99% ee. The synthetic approach involves l-prolinol catalyzed asymmetric epoxidation of cinnamaldehyde followed by Lewis acid-mediated diastereoselective allylation of epoxy aldehyde as the key chiral-inducing steps.
Page(s): 393-398
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(03) [March 2020]

Files in This Item:
File Description SizeFormat 
IJCB 59B(3) 393-398.pdfMain Article151.29 kBAdobe PDFView/Open
IJCB 59B(3) 393-398_Suppl Data.pdfSupplementary Data97.34 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.