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Title: Synthesis, characterization and biological evaluation of novel series of 2-(benzylamino)-2-oxoethyl]-2-oxo-2H-1-benzopyran-3-carboxamide derivatives
Authors: Naik, Mamata Devendra
Bodke, Yadav D
Kumar, Ajeesh A K
Naik, Jayanth K
Shastri, Sudhesh L
Keywords: EDC.HCl;HOBt;Carboxamide;HATU;Diisopropylamine;Molecular docking
Issue Date: Mar-2020
Publisher: NISCAIR-CSIR, India
Abstract: A novel series of benzopyran-3-carboxamide derivatives have been designed and synthesized using a smooth and linear multistep synthesis. Amidation of coumarin-3-carboxylic acid with glycine ethyl ester in the presence of EDC.HCl and HOBt as coupling agent followed by the hydrolysis results in the formation of key synthon, [(2-oxo-2H-1-benzopyran-3-carbonyl) amino] acetic acid 7 which is further coupled with substituted aryl amines using HATU in combination with Hünig’s base to get the target compounds 8(a-h). The synthesized compounds have been screened for their in vitro antibacterial and antioxidant activity and the results are expressed as MIC and IC50 values respectively. Further, the binding ability of synthesized compounds with different proteins have been examined by molecular docking studies.
Page(s): 406-419
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(03) [March 2020]

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