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Title: Synthesis and antimicrobial evaluation of varied ring new heterocycles
Authors: Nisa, Shehneela
Yusuf, Mohamad
Keywords: Chalcone;Pyrazoline;Isoxazoline;Pyrimidine;Benzodiazepine;Benzoxazepine;Benzothiazepine;Antimicrobial
Issue Date: Mar-2020
Publisher: NISCAIR-CSIR, India
Abstract: In the present study, a series of pyrazolines 2a-c, isoxazoline 5, pyrimidines 3aʹ-cʹ and benzoazepines 4aʹʹ-cʹʹ have been prepared from the cyclization reactions of biphenyl chalcone 1 with appropriate binucleophilic reagents. The chalcone 1 has been obtained by using the Claisen-Schmidt condensation reaction of 2-hydroxyacetophenone with biphenyl-4-carboxaldehyde in EtOH/NaOH medium. The structural interpretations of the chalcone 1 and final heterocycles have been fully ascribed on the basis of their different spectroscopic parameters such as IR, 1H and 13C NMR, and ESI-MS. The in vitro antimicrobial evaluation of these heterocycles have also been carried out by using serial tube dilution technique against the selected number of bacterial and fungal strains and most of the studied products proved to be the potent antimicrobial agents. The newly prepared pyrazolines and isoxazoline exhibit noticeable antimicrobial properties.
Page(s): 420-430
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(03) [March 2020]

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