Please use this identifier to cite or link to this item:
|Title:||Synthesis and antimicrobial evaluation of varied ring new heterocycles|
|Abstract:||In the present study, a series of pyrazolines 2a-c, isoxazoline 5, pyrimidines 3aʹ-cʹ and benzoazepines 4aʹʹ-cʹʹ have been prepared from the cyclization reactions of biphenyl chalcone 1 with appropriate binucleophilic reagents. The chalcone 1 has been obtained by using the Claisen-Schmidt condensation reaction of 2-hydroxyacetophenone with biphenyl-4-carboxaldehyde in EtOH/NaOH medium. The structural interpretations of the chalcone 1 and final heterocycles have been fully ascribed on the basis of their different spectroscopic parameters such as IR, 1H and 13C NMR, and ESI-MS. The in vitro antimicrobial evaluation of these heterocycles have also been carried out by using serial tube dilution technique against the selected number of bacterial and fungal strains and most of the studied products proved to be the potent antimicrobial agents. The newly prepared pyrazolines and isoxazoline exhibit noticeable antimicrobial properties.|
|Appears in Collections:||IJC-B Vol.59B(03) [March 2020]|
Files in This Item:
|IJCB 59B(3) 420-430.pdf||Main Article||444.39 kB||Adobe PDF||View/Open|
|IJCB 59B(3) 420-430_Suppl Data.pdf||Supplementary Data||1.63 MB||Adobe PDF||View/Open|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.