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Title: Assay of captopril by residual base neutralisation methods
Authors: Basavaiah, K
Prameela, H C
Keywords: Captopril
Sodium hydroxide
Issue Date: Oct-2004
Publisher: CSIR
IPC CodeInt. Cl.7: A 61 K 9/00
Abstract: Two simple and rapid methods based on two techniques, viz. titrimetry and spectrophotometry are described for the determination of captopril (CPT) in bulk drug and in pharmaceutical formulations. In titrimetry the drug solution is treated with a measured excess quantity of sodium hydroxide followed by back titration of the residual base with hydrochloric acid using phenol red-bromothymol blue as mixed indicator. Spectrophotometry involves the treatment of a fixed amount of sodium hydroxidephenol red mixture with varying amounts of drug and measurement of decrease in absorbance of the dye at 560 nm. In titrimetry, a reaction stoichiometry of 1:1 is found in the quantification range of 5-20 mg of drug. Spectrophotometry allows the determination of CPT between 5 and 30 g/mL with an apparent molar absorptivity of 3.72 × 103 L/mol/cm and a Sandell sensitivity of 58.32 ng/cm2. The present methods are applied successfully for the determination of captopril in pharmaceutical formulations. The validity of the methods is evaluated by parallel determinations using a reference method and by recovery studies.
Page(s): 817-819
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.63(10) [October 2004]

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