Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/54002
Title: Synthesis, characterization, molecular docking studies and biological activity of coumarin linked 2-pyridone heterocycles
Authors: Desai, N C
Karkar, Tushar J
Vekariya, Rajesh H
Joshi, Surbhi B
Jadeja, Krunalsinh A
Vaja, Darshita V
Keywords: Medicinal chemistry;Antibacterial;Antifungal;Cytotoxicity;Molecular docking
Issue Date: Feb-2020
Publisher: NISCAIR-CSIR, India
Abstract: In the present paper, the synthesis, characterization, antimicrobial activity and in┬ásilico molecular docking study of 6-((arylidene)amino)-4-(4-chlorophenyl)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o have been reported. Compounds 4d, 4g, 4j, 4k, 4m and 4o show significant activity. Structure determination of the synthesized compounds has been done by the standard spectroscopic techniques. It is observed that biological activity is influenced by electronic environment of the molecules. Electron withdrawing group at para position plays a major role for enhancing the biological activity for antibacterial activity and the electron donating group at para position for antifungal activity. Compounds 4a-o have been further evaluated for cytotoxicity on HeLa cells. From the cytotoxicity results, compounds have been found to possess low cytotoxicity with potent antimicrobial activity.
Page(s): 231-237
URI: http://nopr.niscair.res.in/handle/123456789/54002
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(02) [February 2020]

Files in This Item:
File Description SizeFormat 
IJCB 59B(2) 231-237.pdfMain Article414.77 kBAdobe PDFView/Open
IJCB 59B(2) 231-237_Suppl Data.pdfSupplementary Data783.59 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.