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Title: Synthesis, characterization, molecular docking studies and biological activity of coumarin linked 2-pyridone heterocycles
Authors: Desai, N C
Karkar, Tushar J
Vekariya, Rajesh H
Joshi, Surbhi B
Jadeja, Krunalsinh A
Vaja, Darshita V
Keywords: Medicinal chemistry;Antibacterial;Antifungal;Cytotoxicity;Molecular docking
Issue Date: Feb-2020
Publisher: NISCAIR-CSIR, India
Abstract: In the present paper, the synthesis, characterization, antimicrobial activity and in┬ásilico molecular docking study of 6-((arylidene)amino)-4-(4-chlorophenyl)-2-oxo-1-((1-(2-oxo-2H-chromen-3-yl)ethylidene)amino)-1,2-dihydropyridine-3,5-dicarbonitriles 4a-o have been reported. Compounds 4d, 4g, 4j, 4k, 4m and 4o show significant activity. Structure determination of the synthesized compounds has been done by the standard spectroscopic techniques. It is observed that biological activity is influenced by electronic environment of the molecules. Electron withdrawing group at para position plays a major role for enhancing the biological activity for antibacterial activity and the electron donating group at para position for antifungal activity. Compounds 4a-o have been further evaluated for cytotoxicity on HeLa cells. From the cytotoxicity results, compounds have been found to possess low cytotoxicity with potent antimicrobial activity.
Page(s): 231-237
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(02) [February 2020]

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