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|Title:||HTIB mediated synthesis of some new 2,4-disubstituted thiazole derivatives using modified HTS via in situ generated tosyloxy ketones|
|Keywords:||[Hydroxy(tosyloxy)iodo]benzene;Modified Hantzch thiazole synthesis;One-pot;Thiazole motif;ɑ-tosyloxy ketones|
|Abstract:||The present study describes the application of HTIB in the synthesis of several new thiazole derivatives, 4-aryl-2-(2-(1-arylethylidene)hydrazinyl)thiazoles and 2-N-acetylhydrazino-4-arylthiazoles starting from aryl methyl ketones and thiosemicarbazones or N-acetylthiosemicarbazide, respectively. The reaction offers a viable method for the construction of thiazole motif in a single-step without the isolation of the intermediate a-tosyloxy carbonyl compound.|
|Appears in Collections:||IJC-B Vol.59B(02) [February 2020]|
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