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Title: HTIB mediated synthesis of some new 2,4-disubstituted thiazole derivatives using modified HTS via in situ generated tosyloxy ketones
Authors: Prakash, Om
Batra, Anita
Pundeer, Rashmi
Keywords: [Hydroxy(tosyloxy)iodo]benzene;Modified Hantzch thiazole synthesis;One-pot;Thiazole motif;ɑ-tosyloxy ketones
Issue Date: Feb-2020
Publisher: NISCAIR-CSIR, India
Abstract: The present study describes the application of HTIB in the synthesis of several new thiazole derivatives, 4-aryl-2-(2-(1-arylethylidene)hydrazinyl)thiazoles and 2-N-acetylhydrazino-4-arylthiazoles starting from aryl methyl ketones and thiosemicarbazones or N-acetylthiosemicarbazide, respectively. The reaction offers a viable method for the construction of thiazole motif in a single-step without the isolation of the intermediate a-tosyloxy carbonyl compound.
Page(s): 247-251
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(02) [February 2020]

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