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Title: Application of novel, efficient and agro-waste sourced catalyst for Knoevenagel condensation reaction
Authors: Kantharaju, K
Hiremath, Prashant B
Keywords: Agro-waste;Knoevenagel reaction;Benzylidinemalononitrile;Coumarin-3-carboxylic acid;Room temperature
Issue Date: Feb-2020
Publisher: NISCAIR-CSIR, India
Abstract: A greener, economic and eco-friendly method for Knoevenagel condensation of aromatic aldehyde, salicylaldehyde with active methylene compounds like malononitrile and Meldrum’s acid to synthesize benzylidinemalononitrile and 3-carboxy coumarin derivatives respectively is demonstrated. The reaction has been carried out in the absence of external base using agro-waste sourced green catalyst WENBA {Water Extract of Nilgiri Bark Ash (Eucalyptus)} as an efficient natural catalytic medium. WENBA is a novel, ecologically safe and inexpensive green catalyst obtained from the agro-waste feedstock. The synthesized compounds benzylidinemalononitrile and 3-carboxy coumarin (2-oxo-2H-1-benzopyran) backbone have multiple applications in medicinal chemistry for the synthesis of bioactive molecules. Thus, a wide number of methodologies have been developed for the synthesis of this class of organic molecules. However, some of the methods reported are associated with hazardous materials and are toxic to the environment. They have longer reaction times, poor yields, and with lower purity of final isolated compound. In spite of a large number of methodologies available for this bioactive molecule synthesis, there is still demand for the development of newer reagents, which give environmentally friendly protocols, mild reaction conditions, inexpensive catalyst and final product isolation in pure form with good yields.
Page(s): 258-270
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.59B(02) [February 2020]

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