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JSIR Vol.64(12) [December 2005] >


Title: Development of a new nasal drug delivery system of diazepam with natural mucoadhesive agent from Trigonella foenum-graecum L
Authors: Datta, Rimi
Bandyopadhyay, A K
Keywords: Diazepam
Nasal drug
Synthetic polymers
Issue Date: Dec-2005
Publisher: CSIR
IPC CodeA61K6/087
Abstract: A new nasal drug delivery system of diazepam has been developed with a natural mucoadhesive agent from fenugreek (Trigonella foenum-graecum L). The mucoadhesive strength, viscosity, gelling property and in vitro drug release characteristics through franz-diffusion cell using excised bovine nasal membrane of this natural mucoadhesive agent was found to be higher in comparison to synthetic polymers, hydroxy propyl methyl cellulose (HPMC) and carbopol 934, which are conventionally used for similar purpose. This patient friendly, needle free dosage form may replace the diazepam injections in future.
Page(s): 973-977
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Source:JSIR Vol.64(12) [December 2005]

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