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IJEB Vol.45(12) [December 2007] >


Title: Role of ATP-sensitive potassium channels in the piracetam induced blockade of opioid effects
Authors: Rehni, Ashish K
Singh, Nirmal
Jindal, Seema
Keywords: ATP-sensitive potassium channels
Antinociception
Opioid receptor
Piracetam
Issue Date: Dec-2007
Publisher: CSIR
Abstract: The present study has been designed to investigate the effect of piracetam on morphine/ buprenorphine-induced antinociception in rats and effect of piracetam on morphine or minoxidil induced relaxation in KCl-precontracted isolated rat aortic ring preparation. Nociceptive threshold was measured by the tail flick test in rats. The cumulative dose responses of morphine or minoxidil were recorded in KCl-precontracted isolated rat aortic ring preparation. Piracetam attenuated buprenorphine-induced antinociception in rats. Piracetam significantly reduced the morphine and minoxidil induced relaxation in KCl precontracted isolated rat aortic ring preparation suggesting that piracetam interferes with opioid receptor and ATP-sensitive potassium channel (KATP) opener mediated responses in vitro. Thus, it may be suggested that piracetam attenuates opioid effects by an opioid receptor-KATP channel linked mechanism.
Page(s): 1050-1054
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.45(12) [December 2007]

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