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Title: Antioxidant DL-alpha lipoic acid as an attenuator of adriamycin induced hepatotoxicity in rat model
Authors: Anandakumar, Padmavathi Pandi
Malarkodi, Saroja Palanichamy
Sivaprasad, Thylambal Rajagopalan
Saravanan, Gandhimathi Dhravidamani
Keywords: Adriamycin;Hepatotoxicity;Lipoic acid
Issue Date: Dec-2007
Publisher: CSIR
Abstract: Protective efficacy of DL-alpha lipoic acid on adriamycin induced hepatotoxicity was evaluated in rats. Adriamycin toxicity, induced by a single injection (ip; 15 mg/kg body wt), was expressed by an elevation in alanine transaminase, aspartate transaminase, bilirubin levels in serum and alkaline phosphatase, lactate dehydrogenase, alanine transaminase, aspartate transaminase activity in hepatic tissue. Adriamycin produced significant increase in malondialdehyde levels indicating tissue lipid peroxidation and potentially inhibiting the activity of antioxidant, reduced glutathione and antioxidant enzymes, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, glucose-6-phosphate dehydrogenase. The present results showed that pretreatment with lipoic acid [75 mg/kg body wt/day (ip), 24 h prior to administration of adriamycin] significantly restored various cellular activity suggesting the antioxidant potential of lipoic acid in ameliorating the hepatotoxicity induced by adriamycin.
Page(s): 1045-1049
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.45(12) [December 2007]

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